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Omar Dounane Selected Research

tacrolimus binding protein 4 (FKBP52)

11/2021Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
10/2016Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons.
3/2014Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.
1/2012Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.

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Omar Dounane Research Topics

Disease

5Tauopathies
11/2021 - 01/2012
5Neurodegenerative Diseases (Neurodegenerative Disease)
11/2021 - 01/2012
4Alzheimer Disease (Alzheimer's Disease)
11/2021 - 01/2012
1Neuroblastoma
11/2021
1Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
11/2021
1Parkinsonian Disorders (Parkinsonism)
01/2012
1Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
01/2012
1Pick Disease of the Brain (Pick's Disease)
01/2012
1Frontotemporal Dementia (Semantic Dementia)
01/2012
1Dementia (Dementias)
01/2012
1Corticobasal Degeneration
01/2012

Drug/Important Bio-Agent (IBA)

4tacrolimus binding protein 4 (FKBP52)IBA
11/2021 - 01/2012
4tau Proteins (tau Protein)IBA
10/2016 - 01/2012
3ImmunophilinsIBA
10/2016 - 01/2012
1Heat-Shock Proteins (Heat-Shock Protein)IBA
11/2021
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
11/2021
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
11/2021
1Phosphopyruvate Hydratase (Enolase)IBA
11/2021
1thiazolyl blueIBA
11/2021
1bafilomycin A1IBA
11/2021
1Cathepsin DIBA
11/2021
1Chloroquine (Aralen)FDA LinkGeneric
11/2021
1Doxycycline (Periostat)FDA LinkGeneric
11/2021
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
11/2021
1Peptidylprolyl Isomerase (Prolyl Isomerase)IBA
11/2021
1Tacrolimus Binding Proteins (FKBP)IBA
11/2021
1UbiquitinIBA
11/2021
1Small Interfering RNA (siRNA)IBA
11/2021
1Proteasome Endopeptidase Complex (Proteasome)IBA
11/2021
1Green Fluorescent ProteinsIBA
11/2021
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
11/2021
1Lysosomal-Associated Membrane Protein 1IBA
11/2021
1Proteins (Proteins, Gene)FDA Link
11/2021
1Retinal Pigments (Pigments, Visual)IBA
11/2021
1RNA (Ribonucleic Acid)IBA
11/2021
1SaltsIBA
11/2021
1TubulinIBA
11/2021
1CaspasesIBA
10/2016
1Leucine (L-Leucine)FDA Link
03/2014
1Proline (L-Proline)FDA Link
03/2014
1Messenger RNA (mRNA)IBA
01/2012